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Improved scale-up synthesis and purification of clinical asthma candidate MIDD0301
We report an improved and scalable synthesis of MIDD0301, a positive GABA(A) receptor modulator that is under development as oral and inhaled treatments for asthma. In contrast to other benzodiazepines in clinical use, MIDD0301 is a chiral compound that has limited brain absorption. The starting mat...
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| Pubblicato in: | Org Process Res Dev |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7497793/ https://ncbi.nlm.nih.gov/pubmed/32952391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.oprd.0c00200 |
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