Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

[Image: see text] Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target of CbA remain unknown. Here, we develop...

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Pubblicato in:ACS Chem Biol
Autori principali: Tranter, Dale, Paatero, Anja O., Kawaguchi, Shinsaku, Kazemi, Soheila, Serrill, Jeffrey D., Kellosalo, Juho, Vogel, Walter K., Richter, Uwe, Mattos, Daphne R., Wan, Xuemei, Thornburg, Christopher C., Oishi, Shinya, McPhail, Kerry L., Ishmael, Jane E., Paavilainen, Ville O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2020
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497630/
https://ncbi.nlm.nih.gov/pubmed/32608972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00325
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