Targeting of HER/ErbB family proteins using broad spectrum Sec61 inhibitors coibamide A and apratoxin A

Coibamide A is a potent cancer cell toxin and one of a select group of natural products that inhibit protein entry into the secretory pathway via a direct inhibition of the Sec61 protein translocon. Many Sec61 client proteins are clinically relevant drug targets once trafficked to their final destin...

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Detalhes bibliográficos
Publicado no:Biochem Pharmacol
Main Authors: Kazemi, Soheila, Kawaguchi, Shinsaku, Badr, Christian E., Mattos, Daphne R., Ruiz-Saenz, Ana, Serrill, Jeffrey D., Moasser, Mark M., Dolan, Brian P., Paavilainen, Ville O., Oishi, Shinya, McPhail, Kerry L., Ishmael, Jane E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7781188/
https://ncbi.nlm.nih.gov/pubmed/33152346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2020.114317
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