Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins

[Image: see text] Coibamide A (CbA) is a marine natural product with potent antiproliferative activity against human cancer cells and a unique selectivity profile. Despite promising antitumor activity, the mechanism of cytotoxicity and specific cellular target of CbA remain unknown. Here, we develop...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Tranter, Dale, Paatero, Anja O., Kawaguchi, Shinsaku, Kazemi, Soheila, Serrill, Jeffrey D., Kellosalo, Juho, Vogel, Walter K., Richter, Uwe, Mattos, Daphne R., Wan, Xuemei, Thornburg, Christopher C., Oishi, Shinya, McPhail, Kerry L., Ishmael, Jane E., Paavilainen, Ville O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7497630/
https://ncbi.nlm.nih.gov/pubmed/32608972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00325
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