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Transduction of Surface and Basal Cells in Rhesus Macaque Lung Following Repeat Dosing with AAV1CFTR
To test the effectiveness of repeat dosing, we sprayed two doses (10(13) vg each) of AAV1Δ27-264-CFTR into airways of four rhesus monkeys at 0 and 30 days, followed by a single dose of 10(13) vg of AAV1GFP on day 60. Monkeys were sacrificed on day 90. No adverse events occurred, indicating that AAV1...
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| Publicado no: | Hum Gene Ther |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc., publishers
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7495919/ https://ncbi.nlm.nih.gov/pubmed/32862701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.207 |
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