Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the translation of ATF4 mRNA through a regulatory 5′ leader sequence with multiple upstream Op...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Vasudevan, Deepika, Neuman, Sarah D., Yang, Amy, Lough, Lea, Brown, Brian, Bashirullah, Arash, Cardozo, Timothy, Ryoo, Hyung Don
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495428/
https://ncbi.nlm.nih.gov/pubmed/32938929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18453-1
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