Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the translation of ATF4 mRNA through a regulatory 5′ leader sequence with multiple upstream Op...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Vasudevan, Deepika, Neuman, Sarah D., Yang, Amy, Lough, Lea, Brown, Brian, Bashirullah, Arash, Cardozo, Timothy, Ryoo, Hyung Don
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495428/
https://ncbi.nlm.nih.gov/pubmed/32938929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18453-1
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak