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Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
The Integrated Stress Response (ISR) helps metazoan cells adapt to cellular stress by limiting the availability of initiator methionyl-tRNA for translation. Such limiting conditions paradoxically stimulate the translation of ATF4 mRNA through a regulatory 5′ leader sequence with multiple upstream Op...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7495428/ https://ncbi.nlm.nih.gov/pubmed/32938929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18453-1 |
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