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SUMOylation Targets Adeno-associated Virus Capsids but Mainly Restricts Transduction by Cellular Mechanisms

Adeno-associated virus (AAV) has proven to be a promising candidate for gene therapy due to its nonpathogenic nature, ease of production, and broad tissue tropism. However, its transduction capabilities are not optimal due to the interaction with various host factors within the cell. In a previous s...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Chen, Qingxin, Njenga, Robin, Leuchs, Barbara, Chiocca, Susanna, Kleinschmidt, Jürgen, Müller, Martin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495375/
https://ncbi.nlm.nih.gov/pubmed/32669341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00871-20
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