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SUMOylation Targets Adeno-associated Virus Capsids but Mainly Restricts Transduction by Cellular Mechanisms

Adeno-associated virus (AAV) has proven to be a promising candidate for gene therapy due to its nonpathogenic nature, ease of production, and broad tissue tropism. However, its transduction capabilities are not optimal due to the interaction with various host factors within the cell. In a previous s...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Chen, Qingxin, Njenga, Robin, Leuchs, Barbara, Chiocca, Susanna, Kleinschmidt, Jürgen, Müller, Martin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7495375/
https://ncbi.nlm.nih.gov/pubmed/32669341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00871-20
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