DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4

Translation efficiency varies considerably between different mRNAs, thereby impacting protein expression. Translation of the stress response master-regulator ATF4 increases upon stress, but the molecular mechanisms are not well understood. We discover here that translation factors DENR, MCTS1 and eI...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Bohlen, Jonathan, Harbrecht, Liza, Blanco, Saioa, Clemm von Hohenberg, Katharina, Fenzl, Kai, Kramer, Günter, Bukau, Bernd, Teleman, Aurelio A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494916/
https://ncbi.nlm.nih.gov/pubmed/32938922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18452-2
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