DENR•MCT-1 Promotes Translation Reinitiation Downstream of uORFs to Control Tissue Growth

During cap-dependent eukaryotic translation initiation, ribosomes scan mRNA from the 5′ end to the first AUG start codon with favorable sequence context(1,2). For many mRNAs this AUG belongs to a short upstream open reading frame (uORF)(3), and translation of the main downstream ORF requires reiniti...

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Hauptverfasser: Schleich, Sibylle, Strassburger, Katrin, Janiesch, Philipp Christoph, Koledachkina, Tatyana, Miller, Katharine K., Haneke, Katharina, Cheng, Yong-Sheng, Kuechler, Katrin, Stoecklin, Georg, Duncan, Kent E., Teleman, Aurelio A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4134322/
https://ncbi.nlm.nih.gov/pubmed/25043021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13401
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