Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

BACKGROUND: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated the relationship between CC, complement and NLRP3 in...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Main Authors: Niyonzima, Nathalie, Bakke, Siril S., Gregersen, Ida, Holm, Sverre, Sandanger, Øystein, Orrem, Hilde L., Sporsheim, Bjørnar, Ryan, Liv, Kong, Xiang Yi, Dahl, Tuva Børresdatter, Skjelland, Mona, Sørensen, Kirsten Krohg, Rokstad, Anne Mari, Yndestad, Arne, Latz, Eicke, Gullestad, Lars, Andersen, Geir Ø., Damås, Jan Kristian, Aukrust, Pål, Mollnes, Tom E., Halvorsen, Bente, Espevik, Terje
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2020
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494683/
https://ncbi.nlm.nih.gov/pubmed/32927275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102985
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