Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis

BACKGROUND: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated the relationship between CC, complement and NLRP3 in...

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Vydáno v:EBioMedicine
Hlavní autoři: Niyonzima, Nathalie, Bakke, Siril S., Gregersen, Ida, Holm, Sverre, Sandanger, Øystein, Orrem, Hilde L., Sporsheim, Bjørnar, Ryan, Liv, Kong, Xiang Yi, Dahl, Tuva Børresdatter, Skjelland, Mona, Sørensen, Kirsten Krohg, Rokstad, Anne Mari, Yndestad, Arne, Latz, Eicke, Gullestad, Lars, Andersen, Geir Ø., Damås, Jan Kristian, Aukrust, Pål, Mollnes, Tom E., Halvorsen, Bente, Espevik, Terje
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494683/
https://ncbi.nlm.nih.gov/pubmed/32927275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102985
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