Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release

Inflammation is associated with development of atherosclerosis, and cholesterol crystals (CC) have long been recognized as a hallmark of atherosclerotic lesions. CC appear early in the atheroma development and trigger inflammation by NLRP3 inflammasome activation. In this study we hypothesized wheth...

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Detalhes bibliográficos
Main Authors: Samstad, Eivind O., Niyonzima, Nathalie, Nymo, Stig, Aune, Marie H., Ryan, Liv, Bakke, Siril S., Lappegård, Knut T., Brekke, Ole-Lars, Lambris, John D., Damås, Jan K., Latz, Eicke, Mollnes, Tom E., Espevik, Terje
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985066/
https://ncbi.nlm.nih.gov/pubmed/24554772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302484
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