A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells

How time is measured by neural stem cells during temporal neurogenesis has remained unresolved. By combining experiments and computational modeling, we define a Shh/Gli-driven three-node timer underlying the sequential generation of motor neurons (MNs) and serotonergic neurons in the brainstem. The...

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Bibliographic Details
Published in:Sci Adv
Main Authors: Dias, José M., Alekseenko, Zhanna, Jeggari, Ashwini, Boareto, Marcelo, Vollmer, Jannik, Kozhevnikova, Mariya, Wang, Hui, Matise, Michael P., Alexeyenko, Andrey, Iber, Dagmar, Ericson, Johan
Format: Artigo
Language:Inglês
Published: American Association for the Advancement of Science 2020
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494341/
https://ncbi.nlm.nih.gov/pubmed/32938678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba8196
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