A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells

How time is measured by neural stem cells during temporal neurogenesis has remained unresolved. By combining experiments and computational modeling, we define a Shh/Gli-driven three-node timer underlying the sequential generation of motor neurons (MNs) and serotonergic neurons in the brainstem. The...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Dias, José M., Alekseenko, Zhanna, Jeggari, Ashwini, Boareto, Marcelo, Vollmer, Jannik, Kozhevnikova, Mariya, Wang, Hui, Matise, Michael P., Alexeyenko, Andrey, Iber, Dagmar, Ericson, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7494341/
https://ncbi.nlm.nih.gov/pubmed/32938678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba8196
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