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Metabolomics and mass spectrometry imaging reveal channeled de novo purine synthesis in cells
Metabolons, multiprotein complexes consisting of sequential enzymes of a metabolic pathway, are proposed to be biosynthetic “hotspots” within the cell. However, experimental demonstration of their presence and functions has remained challenging. We used metabolomics and in situ three-dimensional sub...
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| Publicado en: | Science |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7494208/ https://ncbi.nlm.nih.gov/pubmed/32299949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz6465 |
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