Transport of DNA within cohesin involves clamping on top of engaged heads by Scc2 and entrapment within the ring by Scc3

In addition to extruding DNA loops, cohesin entraps within its SMC-kleisin ring (S-K) individual DNAs during G1 and sister DNAs during S-phase. All three activities require related hook-shaped proteins called Scc2 and Scc3. Using thiol-specific crosslinking we provide rigorous proof of entrapment ac...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Collier, James E, Lee, Byung-Gil, Roig, Maurici Brunet, Yatskevich, Stanislav, Petela, Naomi J, Metson, Jean, Voulgaris, Menelaos, Gonzalez Llamazares, Andres, Löwe, Jan, Nasmyth, Kim A
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7492086/
https://ncbi.nlm.nih.gov/pubmed/32930661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.59560
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