Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells

Although the efficacy of cancer radiotherapy (RT) can be enhanced by targeted immunotherapy, the immunosuppressive factors induced by radiation on tumor cells remain to be identified. Here, we report that CD47-mediated anti-phagocytosis is concurrently upregulated with HER2 in radioresistant breast...

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Publicat a:Nat Commun
Autors principals: Candas-Green, Demet, Xie, Bowen, Huang, Jie, Fan, Ming, Wang, Aijun, Menaa, Cheikh, Zhang, Yanhong, Zhang, Lu, Jing, Di, Azghadi, Soheila, Zhou, Weibing, Liu, Lin, Jiang, Nian, Li, Tao, Gao, Tianyi, Sweeney, Colleen, Shen, Rulong, Lin, Tzu-yin, Pan, Chong-xian, Ozpiskin, Omer M., Woloschak, Gayle, Grdina, David J., Vaughan, Andrew T., Wang, Ji Ming, Xia, Shuli, Monjazeb, Arta M., Murphy, William J., Sun, Lun-Quan, Chen, Hong-Wu, Lam, Kit S., Weichselbaum, Ralph R., Li, Jian Jian
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7490264/
https://ncbi.nlm.nih.gov/pubmed/32929084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18245-7
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