Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice

The cellular prion protein, PrP(C), is a glycosylphosphatidylinositol anchored-membrane glycoprotein expressed most abundantly in neuronal and to a lesser extent in non-neuronal cells. Its conformational conversion into the amyloidogenic isoform in neurons is a key pathogenic event in prion diseases...

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Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS Pathog
Hlavní autoři: Chida, Junji, Hara, Hideyuki, Uchiyama, Keiji, Takahashi, Etsuhisa, Miyata, Hironori, Kosako, Hidetaka, Tomioka, Yukiko, Ito, Toshihiro, Horiuchi, Hiroyuki, Matsuda, Haruo, Kido, Hiroshi, Sakaguchi, Suehiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7489546/
https://ncbi.nlm.nih.gov/pubmed/32845931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008823
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