sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression

Genetic regulation of gene expression, revealed by expression quantitative trait loci (eQTLs), exhibits complex patterns of tissue-specific effects. Characterization of these patterns may allow us to better understand mechanisms of gene regulation and disease etiology. We develop a constrained matri...

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Dettagli Bibliografici
Pubblicato in:Genome Biol
Autori principali: He, Yuan, Chhetri, Surya B., Arvanitis, Marios, Srinivasan, Kaushik, Aguet, François, Ardlie, Kristin G., Barbeira, Alvaro N., Bonazzola, Rodrigo, Im, Hae Kyung, Brown, Christopher D., Battle, Alexis
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488540/
https://ncbi.nlm.nih.gov/pubmed/32912314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-02129-6
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