Personalized cancer therapy prioritization based on driver alteration co-occurrence patterns

Identification of actionable genomic vulnerabilities is key to precision oncology. Utilizing a large-scale drug screening in patient-derived xenografts, we uncover driver gene alteration connections, derive driver co-occurrence (DCO) networks, and relate these to drug sensitivity. Our collection of...

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Dettagli Bibliografici
Pubblicato in:Genome Med
Autori principali: Mateo, Lidia, Duran-Frigola, Miquel, Gris-Oliver, Albert, Palafox, Marta, Scaltriti, Maurizio, Razavi, Pedram, Chandarlapaty, Sarat, Arribas, Joaquin, Bellet, Meritxell, Serra, Violeta, Aloy, Patrick
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Method
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488324/
https://ncbi.nlm.nih.gov/pubmed/32907621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00774-x
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