The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma

BACKGROUND: The Notch signaling pathway has been implicated in the pathogenesis of allergic airway inflammation. Targeting the active Notch transactivation complex by using the cell-permeable, hydrocarbon-stapled synthetic peptide stapled α-helical peptide derived from mastermind-like 1 (SAHM1) resu...

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Détails bibliographiques
Publié dans:J Allergy Clin Immunol
Auteurs principaux: KleinJan, Alex, Tindemans, Irma, Montgomery, Jeffrey E., Lukkes, Melanie, de Bruijn, Marjolein J. W., van Nimwegen, Menno, Bergen, Ingrid, Moellering, Raymond E., Hoogsteden, Henk C., Boon, Louis, Amsen, Derk, Hendriks, R. W.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7488091/
https://ncbi.nlm.nih.gov/pubmed/29111218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2017.08.042
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