Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress

Allergic asthma is mediated by Th2 responses to inhaled allergens. Although previous experiments indicated that Notch signaling activates expression of the key Th2 transcription factor Gata3, it remains controversial how Notch promotes allergic airway inflammation. Here we show that T cell–specific...

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Pubblicato in:J Clin Invest
Autori principali: Tindemans, Irma, van Schoonhoven, Anne, KleinJan, Alex, de Bruijn, Marjolein J.W., Lukkes, Melanie, van Nimwegen, Menno, van den Branden, Anouk, Bergen, Ingrid M., Corneth, Odilia B.J., van IJcken, Wilfred F.J., Stadhouders, Ralph, Hendriks, Rudi W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7324208/
https://ncbi.nlm.nih.gov/pubmed/32255764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI128310
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