Toll-Like Receptor Signaling Drives Btk-Mediated Autoimmune Disease

Bruton's tyrosine kinase (Btk) is a signaling molecule involved in development and activation of B cells through B-cell receptor (BCR) and Toll-like receptor (TLR) signaling. We have previously shown that transgenic mice that overexpress human Btk under the control of the CD19 promoter (CD19-hB...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Rip, Jasper, de Bruijn, Marjolein J. W., Appelman, Marjolein K., Pal Singh, Simar, Hendriks, Rudi W., Corneth, Odilia B. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363707/
https://ncbi.nlm.nih.gov/pubmed/30761150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00095
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