A pathophysiological role of PDE3 in allergic airway inflammation

Phosphodiesterase 3 (PDE3) and PDE4 regulate levels of cyclic AMP, which are critical in various cell types involved in allergic airway inflammation. Although PDE4 inhibition attenuates allergic airway inflammation, reported side effects preclude its application as an antiasthma drug in humans. Case...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Beute, Jan, Lukkes, Melanie, Koekoek, Ewout P., Nastiti, Hedwika, Ganesh, Keerthana, de Bruijn, Marjolein J.W., Hockman, Steve, van Nimwegen, Menno, Braunstahl, Gert-Jan, Boon, Louis, Lambrecht, Bart N., Manganiello, Vince C., Hendriks, Rudi W., KleinJan, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5821178/
https://ncbi.nlm.nih.gov/pubmed/29367458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94888
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