Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury

Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment, particularly by opioids. After SCI, DRG neurons show hyperactivity and chronic depolarization of resting membrane potential (RMP) that is maintained by cAMP signaling through PKA and EPAC. Importantly, SCI also re...

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Vydáno v:J Neurosci
Hlavní autoři: Garza Carbajal, Anibal, Bavencoffe, Alexis, Walters, Edgar T., Dessauer, Carmen W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2020
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486665/
https://ncbi.nlm.nih.gov/pubmed/32690613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0810-20.2020
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