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Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury

Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment, particularly by opioids. After SCI, DRG neurons show hyperactivity and chronic depolarization of resting membrane potential (RMP) that is maintained by cAMP signaling through PKA and EPAC. Importantly, SCI also re...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Garza Carbajal, Anibal, Bavencoffe, Alexis, Walters, Edgar T., Dessauer, Carmen W.
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486665/
https://ncbi.nlm.nih.gov/pubmed/32690613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0810-20.2020
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