Depolarization-Dependent C-Raf Signaling Promotes Hyperexcitability and Reduces Opioid Sensitivity of Isolated Nociceptors after Spinal Cord Injury

Chronic pain caused by spinal cord injury (SCI) is notoriously resistant to treatment, particularly by opioids. After SCI, DRG neurons show hyperactivity and chronic depolarization of resting membrane potential (RMP) that is maintained by cAMP signaling through PKA and EPAC. Importantly, SCI also re...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Garza Carbajal, Anibal, Bavencoffe, Alexis, Walters, Edgar T., Dessauer, Carmen W.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486665/
https://ncbi.nlm.nih.gov/pubmed/32690613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0810-20.2020
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