Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling

Agonist-induced phosphorylation of G protein–coupled receptors (GPCRs) is a key determinant for their interaction with β-arrestins (βarrs) and subsequent functional responses. Therefore, it is important to decipher the contribution and interplay of different receptor phosphorylation sites in governi...

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Vydáno v:Sci Adv
Hlavní autoři: Dwivedi-Agnihotri, Hemlata, Chaturvedi, Madhu, Baidya, Mithu, Stepniewski, Tomasz Maciej, Pandey, Shubhi, Maharana, Jagannath, Srivastava, Ashish, Caengprasath, Natarin, Hanyaloglu, Aylin C., Selent, Jana, Shukla, Arun K.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Association for the Advancement of Science 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7486103/
https://ncbi.nlm.nih.gov/pubmed/32917711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb8368
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