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Growth Optimized Aminoacyl-tRNA Synthetase Levels Prevent Maximal tRNA Charging

Aminoacyl-tRNA synthetases (aaRSs) serve a dual role in charging tRNAs. Their enzymatic activities both provide protein synthesis flux and reduce uncharged tRNA levels. Although uncharged tRNAs can negatively impact bacterial growth, substantial concentrations of tRNAs remain deacylated even under n...

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Détails bibliographiques
Publié dans:Cell Syst
Auteurs principaux: Parker, Darren J., Lalanne, Jean-Benoît, Kimura, Satoshi, Johnson, Grace E., Waldor, Matthew K., Li, Gene-Wei
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484455/
https://ncbi.nlm.nih.gov/pubmed/32726597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.07.005
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