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Characterization of warfarin inhibition kinetics requires stabilization of intramembrane vitamin K epoxide reductases
Intramembrane enzymes are often difficult for biochemical characterization. Human vitamin K epoxide reductase (VKOR) is the target of warfarin. However, this intramembrane enzyme becomes insensitive to warfarin inhibition in vitro, preventing the characterization of inhibition kinetics for decades....
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| Gepubliceerd in: | J Mol Biol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484342/ https://ncbi.nlm.nih.gov/pubmed/32445640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2020.05.009 |
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