Copy Number Loss of 17q22 is Associated with Enzalutamide Resistance and Poor Prognosis in Metastatic Castration-Resistant Prostate Cancer

PURPOSE: The purpose of this study was to measure genomic changes that emerge with enzalutamide treatment using analyses of whole genome sequencing and RNA sequencing. EXPERIMENTAL DESIGN: One hundred and one tumors from men with mCRPC who had not been treated with enzalutamide (n=64) or who had enz...

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Publicado no:Clin Cancer Res
Main Authors: Guan, Xiangnan, Sun, Duanchen, Lu, Eric, Urrutia, Joshua A., Reiter, Robert Evan, Rettig, Matthew, Evans, Christopher P., Lara, Primo, Gleave, Martin, Beer, Tomasz M., Thomas, George V., Huang, Jiaoti, Aggarwal, Rahul R., Quigley, David A., Foye, Adam, Chen, William S., Youngren, Jack, Weinstein, Alana S., Stuart, Joshua M., Feng, Felix Y., Small, Eric J., Xia, Zheng, Alumkal, Joshi J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484240/
https://ncbi.nlm.nih.gov/pubmed/32727885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2303
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