APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). Here we examine the mechanism underlying chromothripsis and kata...

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Published in:Nat Genet
Main Authors: Maciejowski, John, Chatzipli, Aikaterini, Dananberg, Alexandra, Chu, Kevan, Toufektchan, Eleonore, Klimczak, Leszek J., Gordenin, Dmitry A., Campbell, Peter J., de Lange, Titia
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484228/
https://ncbi.nlm.nih.gov/pubmed/32719516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0667-5
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