APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). Here we examine the mechanism underlying chromothripsis and kata...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Nat Genet
Asıl Yazarlar: Maciejowski, John, Chatzipli, Aikaterini, Dananberg, Alexandra, Chu, Kevan, Toufektchan, Eleonore, Klimczak, Leszek J., Gordenin, Dmitry A., Campbell, Peter J., de Lange, Titia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484228/
https://ncbi.nlm.nih.gov/pubmed/32719516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0667-5
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller