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Telomeres in cancer: tumour suppression and genome instability
The shortening of human telomeres has two opposing effects during cancer development. On the one hand, telomere shortening can exert a tumour-suppressive effect through the proliferation arrest induced by activating the kinases ATM and ATR at unprotected chromosome ends. On the other hand, loss of t...
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| Publicado no: | Nat Rev Mol Cell Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589191/ https://ncbi.nlm.nih.gov/pubmed/28096526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2016.171 |
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