Cdc73 suppresses genome instability by mediating telomere homeostasis

Defects in the genes encoding the Paf1 complex can cause increased genome instability. Loss of Paf1, Cdc73, and Ctr9, but not Rtf1 or Leo1, caused increased accumulation of gross chromosomal rearrangements (GCRs). Combining the cdc73Δ mutation with individual deletions of 43 other genes, including T...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS Genet
Hauptverfasser: Nene, Rahul V., Putnam, Christopher D., Li, Bin-Zhong, Nguyen, Katarina G., Srivatsan, Anjana, Campbell, Christopher S., Desai, Arshad, Kolodner, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5779705/
https://ncbi.nlm.nih.gov/pubmed/29320491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007170
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