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Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well un...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Srivatsan, Anjana, Li, Binzhong, Sanchez, Dafne N., Somach, Steven B., da Silva, Vandeclecio L., de Souza, Sandro J., Putnam, Christopher D., Kolodner, Richard D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6717276/
https://ncbi.nlm.nih.gov/pubmed/31409704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906921116
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