Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers

BACKGROUND: Telomeres, located at chromosome ends, are progressively shortened during each cell cycle by replication-dependent loss of DNA termini. Although maintenance of telomere length is critical for cell-replicative potential and tumourigenesis, the erosion of telomeres can lead to genetic inst...

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Detalhes bibliográficos
Main Authors: Rampazzo, E, Bertorelle, R, Serra, L, Terrin, L, Candiotto, C, Pucciarelli, S, Bianco, P Del, Nitti, D, De Rossi, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856015/
https://ncbi.nlm.nih.gov/pubmed/20386541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605644
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