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Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers
BACKGROUND: Telomeres, located at chromosome ends, are progressively shortened during each cell cycle by replication-dependent loss of DNA termini. Although maintenance of telomere length is critical for cell-replicative potential and tumourigenesis, the erosion of telomeres can lead to genetic inst...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Nature Publishing Group
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2856015/ https://ncbi.nlm.nih.gov/pubmed/20386541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605644 |
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