טוען...
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes(1–5). Here we examine the mechanism underlying chromothripsis and kata...
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| הוצא לאור ב: | Nat Genet |
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| Main Authors: | , , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2020
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484228/ https://ncbi.nlm.nih.gov/pubmed/32719516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0667-5 |
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