Tandem deubiquitination and acetylation of SPRTN promotes DNA-protein crosslinks repair and protects against aging

DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that threaten genomic integrity. Recent findings highlight that SPRTN, a specialized DNA-dependent metalloprotease, is a central player in proteolytic cleavage of DPCs. Previous studies suggest that SPRTN deubiquitination is important for it...

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Pubblicato in:Mol Cell
Autori principali: Huang, Jinzhou, Zhou, Qin, Gao, Ming, Nowsheen, Somaira, Zhao, Fei, Kim, Wootae, Zhu, Qian, Kojima, Yusuke, Yin, Ping, Zhang, Yong, Guo, Guijie, Tu, Xinyi, Deng, Min, Luo, Kuntian, Qin, Bo, Machida, Yuichi, Lou, Zhenkun
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484104/
https://ncbi.nlm.nih.gov/pubmed/32649882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.027
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