Φορτώνει......
Tandem deubiquitination and acetylation of SPRTN promotes DNA-protein crosslinks repair and protects against aging
DNA-protein crosslinks (DPCs) are highly toxic DNA lesions that threaten genomic integrity. Recent findings highlight that SPRTN, a specialized DNA-dependent metalloprotease, is a central player in proteolytic cleavage of DPCs. Previous studies suggest that SPRTN deubiquitination is important for it...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Mol Cell |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484104/ https://ncbi.nlm.nih.gov/pubmed/32649882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.027 |
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