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The Two Amino Acids Proximate to the Renin Cleavage Site of Human Angiotensinogen Do Not Affect Blood Pressure and Atherosclerosis in Mice

OBJECTIVE: Renin cleavage of angiotensinogen (AGT) has species specificity. Since the residues at positions 11 and 12 are different between human AGT and mouse AGT, we determined whether these two residues in AGT affect renin cleavage and angiotensin II-mediated blood pressure regulation and atheros...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Wu, Chia-Hua, Wu, Congqing, Howatt, Deborah A., Moorleghen, Jessica J., Cassis, Lisa A., Daugherty, Alan, Lu, Hong S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483780/
https://ncbi.nlm.nih.gov/pubmed/32640904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.120.314048
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