Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2

Older melanoma patients (>50 years old) have poorer prognoses and response rates to targeted therapy compared to young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, espe...

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Publicat a:Cancer Discov
Autors principals: Alicea, Gretchen M., Rebecca, Vito W., Goldman, Aaron R., Fane, Mitchell E., Douglass, Stephen M., Behera, Reeti, Webster, Marie R., Kugel, Curtis H., Ecker, Brett L., Caino, M. Cecilia, Kossenkov, Andrew V., Tang, Hsin-Yao, Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Liu, Qin, Gabrilovich, Dmitry I., Herlyn, Meenhard, Blair, Ian A., Schug, Zachary T., Speicher, David W., Weeraratna, Ashani T.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483379/
https://ncbi.nlm.nih.gov/pubmed/32499221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0329
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