Changes in Aged Fibroblast Lipid Metabolism Induce Age-dependent Melanoma Cell Resistance to Targeted Therapy Via the Fatty Acid Transporter FATP2

Older melanoma patients (>50 years old) have poorer prognoses and response rates to targeted therapy compared to young patients (<50 years old), which can be driven, in part, by the aged microenvironment. Here, we show that aged dermal fibroblasts increase the secretion of neutral lipids, espe...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Discov
Hauptverfasser: Alicea, Gretchen M., Rebecca, Vito W., Goldman, Aaron R., Fane, Mitchell E., Douglass, Stephen M., Behera, Reeti, Webster, Marie R., Kugel, Curtis H., Ecker, Brett L., Caino, M. Cecilia, Kossenkov, Andrew V., Tang, Hsin-Yao, Frederick, Dennie T., Flaherty, Keith T., Xu, Xiaowei, Liu, Qin, Gabrilovich, Dmitry I., Herlyn, Meenhard, Blair, Ian A., Schug, Zachary T., Speicher, David W., Weeraratna, Ashani T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483379/
https://ncbi.nlm.nih.gov/pubmed/32499221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-20-0329
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge