Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho

PURPOSE: Aging is a poor prognostic factor for melanoma. We have shown that melanoma cells in an aged microenvironment, are more resistant to targeted therapy than identical cells in a young microenvironment. This is dependent on age-related secreted factors. Klotho is an age-related protein, whose...

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Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Behera, Reeti, Kaur, Amanpreet, Webster, Marie R., Kim, Suyeon, Ndoye, Abibatou, Kugel, Curtis H., Alicea, Gretchen M., Wang, Joshua, Ghosh, Kanad, Cheng, Phil, Lisanti, Sofia, Marchbank, Katie, Dang, Vanessa, Levesque, Mitchell, Dummer, Reinhard, Xu, Xiaowei, Herlyn, Meenhard, Aplin, Andrew E., Roesch, Alexander, Caino, Cecilia, Altieri, Dario C., Weeraratna, Ashani T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474161/
https://ncbi.nlm.nih.gov/pubmed/28232477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0201
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