ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melanoma

Autophagy mediates resistance to various anticancer agents. In melanoma, resistance to targeted therapy has been linked to expression of Wnt5A, an intrinsic inhibitor of β-catenin, which also promotes invasion. In this study, we assessed the interplay between Wnt5A and autophagy by combining express...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Ndoye, Abibatou, Budina-Kolomets, Anna, Kugel, Curtis H., Webster, Marie, Kaur, Amanpreet, Behera, Reeti, Rebecca, Vito, Li, Ling, Brafford, Patricia, Liu, Qin, Gopal, Y.N. Vashisht, Davies, Michael A., Mills, Gordon B., Xu, Xiaowei, Wu, Hong, Herlyn, Meenhard, Nicastri, Michael, Winkler, Jeffrey, Soengas, Maria S., Amaravadi, Ravi, Murphy, Maureen, Weeraratna, Ashani T.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718045/
https://ncbi.nlm.nih.gov/pubmed/28887323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0907
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