Inhibition of age-related therapy resistance in melanoma by rosiglitazone-mediated induction of Klotho

PURPOSE: Aging is a poor prognostic factor for melanoma. We have shown that melanoma cells in an aged microenvironment, are more resistant to targeted therapy than identical cells in a young microenvironment. This is dependent on age-related secreted factors. Klotho is an age-related protein, whose...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Behera, Reeti, Kaur, Amanpreet, Webster, Marie R., Kim, Suyeon, Ndoye, Abibatou, Kugel, Curtis H., Alicea, Gretchen M., Wang, Joshua, Ghosh, Kanad, Cheng, Phil, Lisanti, Sofia, Marchbank, Katie, Dang, Vanessa, Levesque, Mitchell, Dummer, Reinhard, Xu, Xiaowei, Herlyn, Meenhard, Aplin, Andrew E., Roesch, Alexander, Caino, Cecilia, Altieri, Dario C., Weeraratna, Ashani T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474161/
https://ncbi.nlm.nih.gov/pubmed/28232477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0201
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