Mammalian Atg8 proteins and autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for response to pathogens

Autophagy is a homeostatic process with multiple functions in mammalian cells. Here we show that mammalian Atg8 proteins (mAtg8s) and the autophagy regulator IRGM control TFEB, a transcriptional activator of the lysosomal system. IRGM directly interacted with TFEB and promoted TFEB’s nuclear translo...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Kumar, Suresh, Jain, Ashish, Choi, Seong Won, da Silva, Gustavo Peixoto Duarte, Allers, Lee, Mudd, Michal H., Peters, Ryan Scott, Anonsen, Jan Haug, Rusten, Tor-Erik, Lazarou, Michael, Deretic, Vojo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482486/
https://ncbi.nlm.nih.gov/pubmed/32753672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-020-0549-1
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