mTOR-dependent phosphorylation controls TFEB nuclear export

During starvation the transcriptional activation of catabolic processes is induced by the nuclear translocation and consequent activation of transcription factor EB (TFEB), a master modulator of autophagy and lysosomal biogenesis. However, how TFEB is inactivated upon nutrient refeeding is currently...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Napolitano, Gennaro, Esposito, Alessandra, Choi, Heejun, Matarese, Maria, Benedetti, Valerio, Di Malta, Chiara, Monfregola, Jlenia, Medina, Diego Luis, Lippincott-Schwartz, Jennifer, Ballabio, Andrea
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6098152/
https://ncbi.nlm.nih.gov/pubmed/30120233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05862-6
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